exercise
2 interactions related to exercise
l-arginine + l-citrulline
L-arginine is the direct precursor to nitric oxide but is heavily degraded by intestinal arginase and first-pass hepatic metabolism. L-citrulline bypasses this metabolism and is converted to L-arginine in the kidneys, sustaining elevated plasma arginine for hours rather than minutes when the two are combined.
l-argininel-citrullinenitric-oxidesynergyendothelialblood-pressureexercisevasodilation
caffeine + creatine
Early studies suggested caffeine blunts the ergogenic effect of creatine on muscle phosphocreatine resynthesis and high-intensity performance, but subsequent randomized trials show the combination is generally additive or neutral; the original blunting effect appears specific to chronic co-ingestion during creatine loading rather than acute pre-workout use.
caffeinecreatineergogenicperformancepre-workoutsupplementssports nutritionmuscleexercisetraining