1 interaction related to escitalopram
Escitalopram is a highly selective SSRI metabolized largely by CYP2C19 and CYP3A4. St. John's wort independently inhibits serotonin reuptake and strongly induces these same enzymes plus P-glycoprotein. Combined use risks serotonin syndrome and can also lower escitalopram plasma levels, blunting its antidepressant effect.