epa
6 interactions related to epa
apixaban + fish oil
Apixaban is a direct factor Xa inhibitor that increases bleeding risk on its own. Omega-3 fatty acids in fish oil reduce platelet aggregation in a dose-dependent way; a 2024 JAHA systematic review of 120,643 patients found omega-3 doses of approximately 3 g/day or less of EPA+DHA did not significantly raise bleeding risk, while higher doses (notably high-purity EPA in cardiovascular trials) showed a small absolute increase in bleeding events.
rivaroxaban + fish oil
Omega-3 fatty acids in fish oil have mild antiplatelet and anticoagulant effects, reducing thromboxane A2 and prolonging bleeding time. Combined with rivaroxaban's Factor Xa inhibition, this can additively increase bleeding risk, particularly at fish oil doses above 3 g per day.
aspirin + fish oil
Omega-3 fatty acids in fish oil reduce platelet aggregation and prolong bleeding time slightly, theoretically adding to aspirin's antiplatelet effect. Clinical trials, however, consistently show no clinically significant increase in major bleeding even with high-dose fish oil added to aspirin.
omega-3 + curcumin
Omega-3 fatty acids (EPA and DHA) and curcumin both reduce inflammation through complementary pathways — omega-3s alter cell membrane composition and produce specialized pro-resolving mediators, while curcumin directly inhibits NF-kB and inflammatory cytokine signaling.
omega-3 + vitamin e
Omega-3 fatty acids (EPA and DHA) are polyunsaturated and highly susceptible to oxidation, which can blunt their cardiovascular and anti-inflammatory benefits. Vitamin E (mixed tocopherols) acts as a lipid-soluble antioxidant that protects omega-3 fatty acids from peroxidation both during storage and after absorption.
boswellia + omega-3
Boswellic acids inhibit 5-lipoxygenase to block pro-inflammatory leukotrienes, while EPA and DHA from omega-3s reduce arachidonic acid availability and serve as substrates for specialized pro-resolving mediators (resolvins, protectins) that actively turn off inflammation. The two ingredients suppress inflammation at different steps of the same lipid cascade, giving complementary anti-inflammatory coverage.