enzyme-induction
2 interactions related to enzyme-induction
carvedilol + st. john's wort
Carvedilol is metabolized by CYP2D6, CYP2C9, CYP3A4, and CYP1A2, and is also a P-glycoprotein substrate. St. John's Wort potently induces several of these enzymes and P-gp, accelerating carvedilol clearance and reducing plasma levels, which can blunt its heart failure and antihypertensive effects.
carvedilolst-johns-worthypericumbeta-blockercyp3a4cyp2d6heart-failureenzyme-induction
propranolol + st. john's wort
St. John's Wort potently induces CYP1A2 and CYP2C19 along with CYP3A4 and P-glycoprotein, accelerating the metabolism of propranolol and reducing its plasma levels. Documented cases include loss of intraocular pressure control in glaucoma patients on topical beta-blockers, and the mechanism predicts similar loss of antihypertensive and antiarrhythmic effect with systemic propranolol.
propranololst-johns-worthypericumbeta-blockercyp1a2cyp2c19enzyme-inductionhypertension