enalapril
2 interactions related to enalapril
lithium + ace inhibitors
ACE inhibitors reduce glomerular filtration rate and decrease sodium delivery to the distal nephron, which lowers renal lithium clearance and can raise serum lithium by approximately 36 percent. Toxicity may emerge with delayed onset 3 to 5 weeks after starting the ACE inhibitor, particularly in older adults and those with reduced renal function.
lithiumace inhibitorlisinoprilenalaprilramiprilrenal clearancebipolar disorderhypertensiondrug toxicity
pomegranate + ace inhibitors
Pomegranate polyphenols (pedunculagin, punicalin, gallagic acid) directly inhibit angiotensin-converting enzyme, and clinical trials show pomegranate juice lowers systolic and diastolic blood pressure on its own. Combined with prescription ACE inhibitors the effects can stack, potentially causing additive hypotension, dizziness, or hyperkalemia.
pomegranateace inhibitorslisinoprilramiprilenalaprilblood pressurehypotensionsynergy