elderly
2 interactions related to elderly
phosphatidylserine + omega-3
Phosphatidylserine bound to omega-3 fatty acids (particularly DHA) is more readily incorporated into neuronal membranes than either nutrient alone, supporting membrane fluidity, neurotransmitter release, and memory consolidation. Clinical trials of PS-DHA preparations show improvements in memory and sustained attention in older adults with subjective memory complaints.
melatonin + magnesium
Melatonin signals the brain that it is biological night through MT1 and MT2 receptors in the suprachiasmatic nucleus, while magnesium acts as a NMDA antagonist and GABA-A agonist, helping the nervous system actually relax around that signal. A double-blind RCT in nursing home residents with primary insomnia (Rondanelli 2011) found that nightly melatonin 5 mg + magnesium 225 mg + zinc 11.25 mg significantly improved sleep quality, ease of falling asleep, and morning alertness versus placebo.