drug toxicity
2 interactions related to drug toxicity
lithium + ibuprofen
Ibuprofen and other NSAIDs inhibit renal prostaglandin synthesis, reducing renal blood flow and lithium clearance. This raises serum lithium by approximately 15 to 60 percent, with multiple published cases of clinically significant lithium toxicity after NSAID introduction.
lithiumibuprofennsaidrenal clearancebipolar disorderdrug toxicityprostaglandinspain reliever
lithium + ace inhibitors
ACE inhibitors reduce glomerular filtration rate and decrease sodium delivery to the distal nephron, which lowers renal lithium clearance and can raise serum lithium by approximately 36 percent. Toxicity may emerge with delayed onset 3 to 5 weeks after starting the ACE inhibitor, particularly in older adults and those with reduced renal function.
lithiumace inhibitorlisinoprilenalaprilramiprilrenal clearancebipolar disorderhypertensiondrug toxicity