drug toxicity
2 interactions related to drug toxicity
lithium + ibuprofen
Ibuprofen and other NSAIDs inhibit renal prostaglandin synthesis, which reduces renal blood flow and the kidney's ability to clear lithium. This can raise serum lithium levels, and published case reports describe clinically significant lithium toxicity after an NSAID was started.
lithiumibuprofennsaidrenal clearancebipolar disorderdrug toxicityprostaglandinspain reliever
lithium + ace inhibitors
ACE inhibitors lower the rate at which the kidneys clear lithium, so adding one to lithium therapy tends to raise serum lithium levels. Because lithium has a narrow safety margin, this can push levels toward the toxic range. A distinctive feature is delayed onset: toxicity may not appear for several weeks after the ACE inhibitor is started, especially in older adults and those with reduced kidney function.
lithiumace inhibitorlisinoprilenalaprilramiprilrenal clearancebipolar disorderhypertensiondrug toxicity