drug supplement interaction
8 interactions related to drug supplement interaction
levothyroxine + magnesium
Taking magnesium too close to levothyroxine can modestly reduce how much of the thyroid medicine is absorbed, because magnesium can bind levothyroxine in the gut.
antibiotics + calcium
Calcium can bind to certain antibiotics (tetracyclines and fluoroquinolones) in the gut and reduce how much of the drug is absorbed.
St. John's Wort + SSRI
St. John's Wort is pharmacologically active, not a harmless herb, and it interacts with SSRIs in two overlapping and hard-to-predict ways. The result is a combination most clinicians prefer to avoid rather than manage.
antibiotics + probiotics
Taken at the same moment, an antibiotic can kill bacterial probiotic organisms before they reach the gut, lowering the probiotic's benefit. Spacing the doses apart fixes it.
curcumin + piperine
Piperine (black pepper extract) substantially increases how much curcumin your body absorbs.
metformin + vitamin b12
Long-term metformin use can reduce vitamin B12 absorption, sometimes enough to cause deficiency.
blood thinner + vitamin e
High-dose vitamin E supplements can add to the bleeding risk of anticoagulant and antiplatelet medications by inhibiting platelet aggregation and antagonizing vitamin K–dependent clotting factors.
warfarin + fish oil
Fish oil may modestly add to bleeding risk when combined with warfarin, though most people on stable doses show little change in INR.