drug metabolism
2 interactions related to drug metabolism
rooibos tea + liver enzymes
Rooibos (Aspalathus linearis) is generally well tolerated, but rare case reports describe transient elevations in liver enzymes (AST, ALT) and one report describes acute liver injury after heavy consumption. Rooibos can also modulate hepatic CYP450 enzymes in vitro, creating a theoretical risk of altering metabolism of co-administered drugs.
rooibosliverhepatotoxicityastaltcyp450herbal teadrug metabolism
alprazolam + grapefruit
Grapefruit juice contains furanocoumarins that inhibit intestinal CYP3A4, the enzyme that partially metabolizes alprazolam. The interaction can raise alprazolam blood levels and prolong sedation, although the magnitude is modest compared to other benzodiazepines because alprazolam has high oral bioavailability.
alprazolamxanaxgrapefruitcyp3a4drug metabolismbenzodiazepinefood interactionfuranocoumarin