doxycycline
5 interactions related to doxycycline
antibiotics + calcium
Calcium can bind to certain antibiotics (tetracyclines and fluoroquinolones) in the gut and reduce how much of the drug is absorbed.
antibiotics + probiotics
Taken at the same moment, an antibiotic can kill bacterial probiotic organisms before they reach the gut, lowering the probiotic's benefit. Spacing the doses apart fixes it.
doxycycline + iron
Iron forms an insoluble chelate complex with doxycycline in the gut, sharply reducing absorption of the antibiotic. In controlled human studies, ferrous sulfate taken together with doxycycline cut serum antibiotic levels substantially, which can undermine treatment.
doxycycline + magnesium
Magnesium ions can bind doxycycline in the gastrointestinal tract, forming a poorly absorbed complex that reduces how much antibiotic reaches the bloodstream. Magnesium-containing supplements, antacids, and laxatives can meaningfully lower doxycycline absorption if taken at the same time.
doxycycline + calcium
Calcium binds doxycycline in the gut, forming a complex the body cannot fully absorb. Taking doxycycline together with calcium supplements, calcium-based antacids, or large dairy servings can lower how much antibiotic reaches the bloodstream, though doxycycline binds calcium less than older tetracyclines.