dose dumping
2 interactions related to dose dumping
alcohol + hydrocodone
Hydrocodone and alcohol are both central nervous system depressants. Taken together they cause additive depression of the brainstem breathing centers, which can lead to profound sedation, dangerously slowed or stopped breathing, coma, and death even at otherwise-tolerated opioid doses. Some extended-release hydrocodone formulations can also "dose dump" when combined with alcohol, releasing the dose prematurely. Hydrocodone-acetaminophen products add a separate alcohol-related liver-injury risk.
alcohol + oxycodone
Alcohol and oxycodone are both central nervous system depressants. Taken together they add up, slowing breathing and deepening sedation to a degree that can be life-threatening even when each amount would be tolerated alone. The FDA carries its strongest (boxed) warning on this combination, and national mortality data show alcohol is involved in a meaningful share of opioid overdose deaths.