dose dumping
2 interactions related to dose dumping
alcohol + hydrocodone
Hydrocodone combined with alcohol produces dangerous additive CNS and respiratory depression with high risk of fatal overdose. Extended-release hydrocodone formulations can experience dose dumping when combined with alcohol, releasing the entire dose at once and causing potentially lethal blood concentrations.
alcoholhydrocodonevicodinnorcoopioidrespiratory depressionboxed warningdose dumping
alcohol + oxycodone
Combining alcohol with oxycodone causes additive central nervous system and respiratory depression, dramatically increasing the risk of fatal overdose, sedation, and impaired breathing. Alcohol can also accelerate the release of oxycodone from extended-release formulations, causing dangerous spikes in blood levels.
alcoholoxycodoneopioidrespiratory depressionoverdosecns depressantboxed warningdose dumping