diphenhydramine
2 interactions related to diphenhydramine
diphenhydramine + valerian
Diphenhydramine (a sedating antihistamine) and valerian root both produce CNS depression through GABAergic and histaminergic pathways. Used together, sedation, psychomotor impairment, and respiratory depression risks are additive.
diphenhydraminevalerianbenadrylsedationsleep aidcns depressionherbalinsomnia
diphenhydramine + melatonin
Both diphenhydramine and melatonin cause sedation through different mechanisms (H1 antagonism and MT1/MT2 agonism). Combined use produces additive CNS depression, next-day drowsiness, impaired cognition, and increased fall risk, especially in older adults.
diphenhydraminemelatoninbenadrylsedationsleep aidcns depressionbeers criteriainsomnia