1 interaction related to digoxin toxicity
There is no major direct chemical clash between alcohol and digoxin, but alcohol works indirectly to make digoxin less safe. Alcohol can trigger irregular heart rhythms (so-called holiday heart) and, along with diuretics, deplete potassium and magnesium. Because digoxin has a narrow safety margin, those electrolyte shifts make the heart more sensitive to it and raise the risk of digoxin toxicity. Heavy drinking can also worsen the heart failure digoxin is meant to treat.
