dha
6 interactions related to dha
apixaban + fish oil
Apixaban is a direct factor Xa inhibitor that raises bleeding risk on its own. Omega-3 fatty acids in fish oil have a mild antiplatelet effect that can theoretically add to that risk. A large 2024 systematic review and meta-analysis found that typical supplement-level omega-3 intake did not significantly raise bleeding risk, with only a small absolute increase seen at very high, prescription-strength doses. Standard fish oil is generally compatible with apixaban when the prescriber is aware, while high-dose omega-3 should be cleared with a clinician.
rivaroxaban + fish oil
Omega-3 fatty acids in fish oil have a mild antiplatelet effect, slightly shifting platelet thromboxane production and modestly lengthening bleeding time. Rivaroxaban blocks Factor Xa to reduce clotting. The two act through different pathways, so the combination is additive in theory, but clinical evidence suggests the real-world bleeding effect is small. A large randomized trial found no increase in bleeding even with high-dose fish oil.
aspirin + fish oil
Omega-3 fatty acids in fish oil mildly reduce platelet aggregation, which in theory adds to aspirin's antiplatelet effect. In practice, clinical studies have not found a clinically significant increase in major bleeding when standard fish oil is combined with aspirin.
omega-3 + curcumin
Omega-3 fatty acids (EPA and DHA) and curcumin lower inflammation through complementary pathways — omega-3s remodel cell membranes and generate specialized pro-resolving mediators, while curcumin inhibits NF-kB and downstream inflammatory cytokine signaling. Human trials in migraine patients show the combination can reduce inflammatory markers more than either alone.
omega-3 + vitamin e
Omega-3 fatty acids (EPA and DHA) are polyunsaturated and highly susceptible to oxidation, which can blunt their cardiovascular and anti-inflammatory benefits. Vitamin E acts as a lipid-soluble antioxidant that helps protect omega-3 fatty acids from peroxidation both during storage and after absorption, which is why most quality fish oils already include a small amount of mixed tocopherols.
boswellia + omega-3
Boswellic acids inhibit 5-lipoxygenase to reduce pro-inflammatory leukotrienes, while EPA and DHA from omega-3s lower the arachidonic acid available to inflammatory enzymes and serve as substrates for specialized pro-resolving mediators (resolvins, protectins) that help switch inflammation off. The two act at different steps of the same lipid cascade, giving complementary anti-inflammatory coverage. Evidence in joint pain is modest but consistent.