cyp450
2 interactions related to cyp450
rooibos tea + liver enzymes
Rooibos (Aspalathus linearis) is generally well tolerated. A small number of case reports describe transient elevations in liver enzymes (AST, ALT) with heavy or prolonged consumption, though the clearest acute-injury report involved rooibos taken together with another herb rather than rooibos alone. Laboratory (in vitro) work suggests rooibos can modulate hepatic CYP450 enzymes, which raises a theoretical, unproven possibility of affecting the metabolism of some co-administered drugs.
rooibosliverhepatotoxicityastaltcyp450herbal teadrug metabolism
smoking + hrt
Smoking speeds up how the liver breaks down estradiol, lowering circulating estrogen and reducing the effectiveness of oral hormone replacement therapy. It also adds to the blood-clot risk that oral HRT already carries.
smokinghrthormone replacement therapyestradiolmenopausecyp450transdermalvteestrogen metabolismbone loss