cyp450
2 interactions related to cyp450
rooibos tea + liver enzymes
Rooibos (Aspalathus linearis) is generally well tolerated, but rare case reports describe transient elevations in liver enzymes (AST, ALT) and one report describes acute liver injury after heavy consumption. Rooibos can also modulate hepatic CYP450 enzymes in vitro, creating a theoretical risk of altering metabolism of co-administered drugs.
rooibosliverhepatotoxicityastaltcyp450herbal teadrug metabolism
smoking + hrt
Smoking accelerates hepatic CYP-mediated metabolism of estradiol, lowering circulating estrogen levels and reducing the efficacy of oral hormone replacement therapy for menopausal symptoms and bone protection. It also compounds the venous thromboembolism risk of oral HRT.
smokinghrthormone replacement therapyestradiolmenopausecyp450transdermalvteestrogen metabolismbone loss