cyp3a4 induction
2 interactions related to cyp3a4 induction
amitriptyline + st. john's wort
St. John's wort induces CYP3A4 and CYP2D6 enzymes that metabolize amitriptyline, reducing its plasma concentrations by up to 22%, while simultaneously adding serotonergic activity that can trigger serotonin syndrome. The combined result is paradoxical: less antidepressant effect plus higher risk of a potentially fatal serotonin reaction.
amitriptylinest johns wortserotonin syndrometricycliccyp3a4 inductionantidepressant interactionherbal interactiontca
nortriptyline + st. john's wort
St. John's wort induces CYP3A4 and CYP2D6, the enzymes responsible for metabolizing nortriptyline, reducing nortriptyline blood levels and antidepressant effect. The herb also adds serotonergic activity that may increase risk of serotonin syndrome.
nortriptylinest johns worttcacyp2d6cyp3a4 inductionantidepressant interactionserotoninherbal interaction