cyp2e1
2 interactions related to cyp2e1
alcohol + vitamin a
Alcohol depletes hepatic vitamin A by inducing cytochrome P450 enzymes (especially CYP2E1, CYP26A1, CYP26B1) that catabolize retinol. Paradoxically, vitamin A supplementation in heavy drinkers is hepatotoxic — alcohol potentiates retinol's toxicity to liver cells, and high-dose beta-carotene combined with alcohol increases liver injury.
alcoholvitamin aretinolbeta caroteneliver diseasehepatotoxicitycyp2e1carotenoid
acetaminophen + milk thistle
Milk thistle's active component silymarin reduces CYP2E1 activity and supports hepatic glutathione, both of which limit formation of the toxic acetaminophen metabolite NAPQI. Animal studies show clear protection, and the combination is considered low-risk; clinical benefit in humans is plausible but not firmly established.
acetaminophenmilk thistlesilymarinliverhepatoprotectivecyp2e1glutathionepain