cyp2e1
2 interactions related to cyp2e1
alcohol + vitamin a
Alcohol depletes the liver's vitamin A by inducing cytochrome P450 enzymes (notably CYP2E1) that break retinol down into toxic byproducts. Adding high-dose vitamin A or beta-carotene supplements on top of regular drinking can worsen liver injury rather than correct the deficiency, so repletion in drinkers is not as simple as taking a pill.
acetaminophen + milk thistle
Milk thistle's active component silymarin reduces CYP2E1 activity and supports hepatic glutathione, the same pathways that govern acetaminophen safety, so it may add a mild margin of liver support. The protective effect is shown mainly in animal studies; human clinical benefit is plausible but not established. The combination is considered low-risk, but milk thistle is not a substitute for safe acetaminophen dosing and is never a treatment for overdose.