cyp

paroxetine + st. john's wort

Paroxetine is an SSRI that raises serotonin by blocking its reuptake. St. John's wort independently raises serotonin and also induces drug-metabolizing enzymes and P-glycoprotein. Taken together, the additive serotonin effect can precipitate serotonin syndrome, and paroxetine is among the most frequently implicated SSRIs in published St. John's wort case reports.