crocus sativus
2 interactions related to crocus sativus
fluoxetine + saffron
Saffron (Crocus sativus) has independent antidepressant activity, including serotonergic effects demonstrated in randomized controlled trials, and combining it with fluoxetine can theoretically add to serotonergic tone. Fluoxetine's long half-life extends the window of potential interaction for weeks after the last dose.
saffron + curcumin
Saffron (Crocus sativus) and curcumin both have antidepressant effects through complementary mechanisms: saffron modulates serotonin reuptake and increases BDNF, while curcumin reduces neuroinflammation and supports monoamine balance via MAO inhibition and HPA-axis modulation. A randomized placebo-controlled trial in major depressive disorder showed the combination was effective in reducing depressive and anxiolytic symptoms.