crestor
2 interactions related to crestor
rosuvastatin + coq10
Rosuvastatin blocks HMG-CoA reductase, the enzyme that makes both cholesterol and coenzyme Q10, so it modestly lowers circulating CoQ10. The depletion is generally smaller than with fat-soluble statins, and mitochondrial impairment is only one proposed mechanism for statin-associated muscle symptoms. This is a possible-benefit pairing, not a dangerous one.
rosuvastatin + berberine
Rosuvastatin is carried into liver cells by the OATP1B1 transporter. In a laboratory study using human liver-cell cultures, berberine increased OATP1B1 activity and pushed more rosuvastatin into the cells. This is an early, test-tube signal only: there is no human or animal data showing it changes blood levels, cholesterol response, or side-effect risk in real life.