cofactor
2 interactions related to cofactor
vitamin b1 + magnesium
Magnesium is the cofactor that converts thiamine (vitamin B1) into its active coenzyme form, thiamine pyrophosphate (TPP). When magnesium is low, thiamine cannot activate fully, so a thiamine supplement may produce little benefit until magnesium status is restored. The two work together rather than against each other.
nac + selenium
NAC supplies cysteine, the rate-limiting building block for glutathione synthesis, while selenium is the cofactor built into the glutathione peroxidase enzymes that use glutathione to neutralize peroxides. The two nutrients support the same antioxidant pathway, so on a mechanistic level each helps the other work. Combined clinical benefit beyond that shared pathway is not well demonstrated, and the pairing is low-risk.