citrus
2 interactions related to citrus
blood orange + simvastatin
Blood orange (Citrus sinensis var.) is a sweet orange and does not contain the furanocoumarins (bergamottin, 6',7'-dihydroxybergamottin) that drive the grapefruit-statin interaction. Published reviews of citrus furanocoumarin content list blood orange among the sweet oranges as essentially free of clinically significant CYP3A4-inhibiting compounds.
blood orangesweet orangesimvastatinstatincyp3a4furanocoumarinsafe combinationcitrus
pomelo + simvastatin
Pomelo (Citrus maxima) contains furanocoumarins that irreversibly inhibit intestinal CYP3A4, the enzyme that metabolizes simvastatin during first-pass absorption. With CYP3A4 disabled, simvastatin plasma concentrations rise substantially, increasing the risk of myopathy and rhabdomyolysis.
pomelosimvastatinstatincyp3a4furanocoumarinrhabdomyolysismyopathyfood-drug interactioncitrus