chlorogenic acid
2 interactions related to chlorogenic acid
levothyroxine + coffee
Coffee can reduce how much levothyroxine you absorb when the two are taken at the same time. Chlorogenic acids and other compounds in coffee appear to bind the hormone in the gut, and coffee can also speed gastric transit, leaving less time for the tablet to dissolve. The effect largely disappears when the dose and the coffee are separated by enough time.
levothyroxinecoffeeabsorptionthyroidcaffeinetiminghypothyroidismchlorogenic acid
coffee + iron
Coffee contains chlorogenic acid and other polyphenols with galloyl groups that bind non-heme iron in the gut, forming poorly soluble complexes the intestine cannot absorb. Drinking coffee with or shortly after an iron-rich meal or supplement meaningfully reduces how much non-heme iron you take up.
coffeeironabsorptionanemiapolyphenolschlorogenic acidnon-heme irontiming