1 interaction related to cequel
In a randomized controlled trial of bipolar depression (CEQUEL), adding folic acid to lamotrigine appeared to blunt lamotrigine's antidepressant benefit, an effect seen mainly in people carrying the COMT Met allele. The interaction is pharmacodynamic, not pharmacokinetic, so lamotrigine blood levels stay unchanged. The exact mechanism is not established, and the signal is limited to bipolar depression rather than epilepsy.
