case report
2 interactions related to case report
pomelo + tacrolimus
Pomelo contains furanocoumarins that inhibit intestinal CYP3A4 and P-glycoprotein, the two systems that limit tacrolimus absorption. A documented case in a renal transplant patient showed pomelo consumption nearly doubled tacrolimus blood levels, risking nephrotoxicity and neurotoxicity given tacrolimus's narrow therapeutic window.
pomelotacrolimustransplantcyp3a4p-glycoproteinfuranocoumarinimmunosuppressantnephrotoxicitycase report
star fruit + phenytoin
Star fruit (Averrhoa carambola) contains caramboxin, a neurotoxin that activates excitatory neuroreceptors and inhibits GABA, and high oxalate content that causes acute kidney injury. In patients with renal impairment, star fruit ingestion has triggered refractory status epilepticus, directly antagonizing phenytoin's seizure-prevention purpose.
star fruitcarambolaphenytoinseizurestatus epilepticuscaramboxinepilepsynephrotoxicitycase report