carvedilol
2 interactions related to carvedilol
carvedilol + st. john's wort
Carvedilol is partly broken down by liver enzymes (including CYP2C9 and CYP3A4) and is also a P-glycoprotein substrate. St. John's Wort induces several of these enzymes and P-glycoprotein, which can speed carvedilol clearance and lower its blood levels, potentially weakening its blood-pressure and heart-failure effects. The interaction is mechanism-based and extrapolated from St. John's Wort's effect on similar drugs; no direct human study of this specific pair has been published.
cbd + beta-blockers
CBD weakly inhibits CYP2D6, the liver enzyme that clears beta-blockers such as metoprolol, propranolol, and carvedilol, so in theory it could nudge their plasma levels up. CBD also has a mild blood-pressure-lowering effect of its own. Both actions point in the same direction as the beta-blocker, but the CYP2D6 effect is weak and its real-world clinical significance has not been demonstrated in humans.