carvedilol
2 interactions related to carvedilol
carvedilol + st. john's wort
Carvedilol is metabolized by CYP2D6, CYP2C9, CYP3A4, and CYP1A2, and is also a P-glycoprotein substrate. St. John's Wort potently induces several of these enzymes and P-gp, accelerating carvedilol clearance and reducing plasma levels, which can blunt its heart failure and antihypertensive effects.
carvedilolst-johns-worthypericumbeta-blockercyp3a4cyp2d6heart-failureenzyme-induction
cbd + beta-blockers
CBD inhibits several CYP450 enzymes (notably CYP3A4, CYP2C19, CYP2C9, CYP1A2) and may modestly inhibit CYP2D6. Beta-blockers such as metoprolol, propranolol, and carvedilol are metabolized via CYP2D6 (and CYP1A2 for propranolol), so co-use can raise beta-blocker plasma levels, with additive blood-pressure lowering and bradycardia.
cbdbeta-blockersmetoprololpropranololcarvedilolcyp2d6bradycardiahypotensiondrug interaction