cannabis
3 interactions related to cannabis
thc + alcohol
Drinking alcohol alongside cannabis raises the peak blood level of THC and its active metabolite from the same amount of cannabis, and the two substances produce additive impairment of coordination, judgment, and reaction time. The combination is one of the most frequently detected in drivers involved in fatal crashes.
cannabis + ssris
Cannabinoids inhibit liver enzymes (including CYP2C19) that clear several SSRIs such as sertraline, citalopram, and escitalopram, which can raise SSRI plasma levels. Cannabinoids also touch the serotonin system, and case reports describe serotonin syndrome precipitated by high-potency cannabis in patients on serotonergic regimens.
thc + benzodiazepines
THC (the main psychoactive compound in cannabis) and benzodiazepines both depress the central nervous system, so combining them adds up to stronger sedation, impaired coordination, memory problems, and slowed breathing. Cannabinoids, especially CBD, can also inhibit the liver enzyme CYP3A4 that clears several benzodiazepines, raising and prolonging their levels.