cannabis
3 interactions related to cannabis
thc + alcohol
Co-administration of alcohol with THC significantly increases peak blood THC and 11-OH-THC concentrations versus cannabis alone, and produces additive impairment of psychomotor performance, judgment, and reaction time.
cannabis + ssris
Cannabis cannabinoids inhibit CYP2C19, CYP2C9, and CYP3A4, raising plasma levels of SSRIs such as sertraline, citalopram, and escitalopram. Cannabinoids also modulate serotonin signaling, and case reports describe serotonin syndrome precipitated by high-potency cannabis in patients on SSRIs.
thc + benzodiazepines
THC and benzodiazepines are both central-nervous-system depressants and produce additive sedation, ataxia, cognitive impairment, and respiratory slowing. THC and CBD components of cannabis also inhibit CYP3A4, which metabolizes alprazolam, midazolam, and triazolam, potentially raising benzodiazepine plasma levels.