calcineurin inhibitor
2 interactions related to calcineurin inhibitor
cbd + tacrolimus
CBD inhibits CYP3A4, CYP3A5, and P-glycoprotein, the main pathways that clear tacrolimus. A published case report documented an approximately 3-fold rise in dose-normalized tacrolimus levels after adding CBD, posing serious nephrotoxicity, neurotoxicity, and over-immunosuppression risk in transplant patients.
cbdtacrolimustransplantcyp3a4p-glycoproteinimmunosuppressantcalcineurin inhibitordrug interactionnephrotoxicity
lactobacillus + tacrolimus
Tacrolimus is a calcineurin-inhibitor immunosuppressant used after solid-organ transplant. Lactobacillus species have caused bacteremia, endocarditis, and liver abscess in transplant recipients on tacrolimus, including a published case of recurrent Lactobacillus rhamnosus bacteremia in a renal transplant patient.
lactobacillustacrolimusprograftransplantbacteremiacalcineurin inhibitorimmunosuppressionrenal transplant