bone loss
3 interactions related to bone loss
prednisone + calcium
Glucocorticoids like prednisone impair intestinal calcium absorption and increase urinary calcium loss, contributing to negative calcium balance and accelerated bone loss. This is a depletion-and-displacement effect, not a chemical interaction in the gut.
methylprednisolone + vitamin d
Methylprednisolone, like other glucocorticoids, is associated with increased catabolism of 25-hydroxyvitamin D and impaired vitamin D-mediated intestinal calcium absorption. Long-term use contributes to vitamin D deficiency and accelerated bone loss.
smoking + hrt
Smoking accelerates hepatic CYP-mediated metabolism of estradiol, lowering circulating estrogen levels and reducing the efficacy of oral hormone replacement therapy for menopausal symptoms and bone protection. It also compounds the venous thromboembolism risk of oral HRT.