1 interaction related to black-pepper
Piperine, the active alkaloid in black pepper, can inhibit intestinal P-glycoprotein and several liver enzymes that normally limit how much propranolol reaches the bloodstream. A small human study found that concentrated piperine raised propranolol's blood levels, so a stable dose may behave like a somewhat higher one, slightly amplifying its blood-pressure and heart-rate effects. Culinary pepper is not the concern; concentrated piperine supplements are.
