beta carotene

alcohol + vitamin a

Alcohol depletes the liver's vitamin A by inducing cytochrome P450 enzymes (notably CYP2E1) that break retinol down into toxic byproducts. Adding high-dose vitamin A or beta-carotene supplements on top of regular drinking can worsen liver injury rather than correct the deficiency, so repletion in drinkers is not as simple as taking a pill.