1 interaction related to bergamottin
Bergamot orange (Citrus bergamia) is the source of bergamottin, the prototype furanocoumarin that inactivates CYP3A4. Bergamot juice and concentrated bergamot polyphenol supplements (often marketed for cholesterol) could in theory raise levels of CYP3A4-metabolized statins (simvastatin, atorvastatin, lovastatin). The mechanism is well established in the lab and in animals, but no direct human pharmacokinetic studies of bergamot with statins exist, so the real-world magnitude is uncertain.
