benadryl
2 interactions related to benadryl
diphenhydramine + valerian
Diphenhydramine (a sedating antihistamine) and valerian root both depress the central nervous system, through histaminergic and GABAergic pathways respectively. Taken together their sedative effects add up, increasing drowsiness, next-day impairment, and fall risk.
diphenhydraminevalerianbenadrylsedationsleep aidcns depressionherbalinsomnia
diphenhydramine + melatonin
Diphenhydramine and melatonin both promote sleepiness through different mechanisms (H1 antihistamine blockade and MT1/MT2 receptor activation). Used together they have an additive sedating effect, which can mean heavier-than-expected drowsiness, lingering next-day grogginess, slower reaction time, and a higher fall risk, especially in older adults.
diphenhydraminemelatoninbenadrylsedationsleep aidcns depressionbeers criteriainsomnia