1 interaction related to behavioral side effects
Levetiracetam (Keppra) commonly causes behavioral side effects including irritability, agitation, anxiety, and mood changes (sometimes called 'Keppra rage'). Randomized trials and case series in children and adults suggest that adding pyridoxine (vitamin B6) eases these behavioral symptoms in a meaningful subset of patients, though the evidence is mixed: two pediatric trials were positive while one adult trial was null. This is a potential benefit, not a harmful interaction.
