atrial fibrillation
2 interactions related to atrial fibrillation
amiodarone + grapefruit
Grapefruit juice inhibits intestinal CYP3A4, raising oral amiodarone AUC by approximately 50% and peak levels by 84% while abolishing production of its active metabolite N-desethylamiodarone. The FDA-approved Pacerone label explicitly states grapefruit juice should not be consumed during oral amiodarone treatment.
amiodaronegrapefruitcyp3a4antiarrhythmicqt prolongationatrial fibrillationdrug-food interactionfda label warning
alcohol + digoxin
Alcohol can precipitate atrial fibrillation and other arrhythmias that overlap with digoxin's narrow therapeutic window; concurrent diuretic-induced hypokalemia and hypomagnesemia, common in this population, sharply increase the risk of digoxin toxicity. Alcohol may also alter digoxin absorption and worsen heart failure that the drug is meant to treat.
alcoholdigoxinheart failureatrial fibrillationarrhythmiapotassiumdigoxin toxicityholiday heart