ascorbic acid

7 interactions related to ascorbic acid

glutathione + vitamin c

Vitamin C reduces oxidized glutathione (GSSG) back to reduced glutathione (GSH) via the ascorbate-glutathione cycle, while glutathione in turn regenerates oxidized vitamin C (dehydroascorbate) back to ascorbate. The two antioxidants mutually recycle each other and maintain cellular redox balance.

low
glutathionevitamin cascorbic acidantioxidantredoxsynergyrecyclingliver

nac + vitamin c

NAC supplies cysteine for glutathione synthesis while vitamin C reduces oxidized glutathione (GSSG) back to its active form (GSH) and directly scavenges aqueous-phase free radicals. The two work together to maintain a high GSH:GSSG ratio inside cells.

low
nacvitamin cascorbic acidglutathioneantioxidantliverdetoxsynergy

collagen + vitamin c

Vitamin C is an essential cofactor for prolyl and lysyl hydroxylase, the enzymes that hydroxylate proline and lysine residues during collagen synthesis and stabilize the triple-helix structure. Taking collagen peptides with vitamin C supplies both the amino acid building blocks and the enzymatic cofactor required to convert them into functional new collagen.

low
collagenvitamin cskinjointtendonsynergyhydroxylationascorbic acid

vitamin c + glucose meter

Vitamin C (ascorbic acid) is a strong reducing agent that interferes with the electrochemical reactions used by many home and hospital glucose meters, producing falsely elevated blood glucose readings, especially with glucose dehydrogenase (GDH-PQQ) and some glucose oxidase strip chemistries. Cases have been reported where high-dose vitamin C therapy led to a wrong diagnosis of diabetic ketoacidosis and inappropriate insulin treatment.

high
vitamin cascorbic acidglucose meterblood glucosediabeteslab interferenceglucose oxidasefalse high glucose

smoking + vitamin c

Smoking increases oxidative stress and accelerates the metabolic turnover of vitamin C, lowering plasma and leukocyte ascorbic acid levels. The NIH Food and Nutrition Board officially recommends that smokers consume an additional 35 mg of vitamin C daily above the standard RDA.

moderate
smokingvitamin cascorbic acidantioxidantoxidative stressnih odsrdasupplementationsmokersnutrient depletion

vitamin c + stool occult blood test

Vitamin C (ascorbic acid) is a reducing agent that blocks the guaiac peroxidase color reaction used in traditional fecal occult blood tests (gFOBT, including Hemoccult), producing a falsely negative result even when significant gastrointestinal bleeding is present. Doses of 250 mg per day or higher have been documented to cause false negatives, leading to missed diagnoses of colorectal bleeding sources.

moderate
vitamin cascorbic acidfecal occult bloodhemoccultcolorectal cancer screeningfobtfit testlab interference

whey protein + iron

Whey protein contains calcium and bioactive peptides that can chelate iron in the gut and reduce its absorption. Studies in iron-fortified casein-whey drinks show calcium added with whey reduces iron absorption by approximately 18 to 27 percent.

moderate
whey proteinironabsorptioncalciumsupplementascorbic acidbioavailabilitychelation