arrhythmia
9 interactions related to arrhythmia
omeprazole + magnesium
Long-term omeprazole use (typically >1 year) is associated with hypomagnesemia, likely via impaired active intestinal magnesium transport through TRPM6/TRPM7 channels. The FDA issued a formal Drug Safety Communication in 2011 warning of serious adverse events including arrhythmia, tetany, and seizures.
pantoprazole + magnesium
Pantoprazole, like all PPIs, is associated with hypomagnesemia after long-term use, likely via impaired active intestinal magnesium transport (TRPM6/TRPM7). The FDA included pantoprazole in its 2011 Drug Safety Communication on PPI-induced hypomagnesemia, which can cause arrhythmia, tetany, and seizures.
furosemide + magnesium
Furosemide inhibits the Na-K-2Cl cotransporter, which abolishes the lumen-positive voltage driving paracellular magnesium reabsorption in the thick ascending limb. Long-term loop diuretic use causes urinary magnesium wasting and hypomagnesemia, which worsens loop-diuretic hypokalemia and increases arrhythmia risk.
dairy + digoxin
Dairy products contribute calcium that, when combined with intravenous calcium or high oral loads, can potentiate digoxin's effects on the heart and increase the risk of arrhythmias. Dietary fiber and milk proteins may also modestly reduce digoxin absorption from oral capsules and tablets.
alcohol + digoxin
Alcohol can precipitate atrial fibrillation and other arrhythmias that overlap with digoxin's narrow therapeutic window; concurrent diuretic-induced hypokalemia and hypomagnesemia, common in this population, sharply increase the risk of digoxin toxicity. Alcohol may also alter digoxin absorption and worsen heart failure that the drug is meant to treat.
energy drinks + beta-blockers
Energy drinks raise sympathetic tone through caffeine, taurine, and guarana, opposing the heart-rate and blood-pressure lowering effects of beta-blockers like metoprolol, atenolol, propranolol, and bisoprolol. Case reports document refractory arrhythmias and hypertensive episodes in patients on beta-blocker therapy who consumed energy drinks regularly.
licorice tea + digoxin
Licorice (Glycyrrhiza glabra) contains glycyrrhizin, which inhibits renal 11-beta-hydroxysteroid dehydrogenase type 2 and causes potassium loss through mineralocorticoid-like activity. The resulting hypokalemia sharply increases digoxin's binding to cardiac Na/K-ATPase, raising the risk of life-threatening digoxin toxicity and arrhythmia.
alcohol + magnesium
Alcohol acts as an acute magnesium diuretic, dramatically increasing urinary magnesium excretion within hours of intake. Chronic drinking depletes body magnesium stores through this renal wasting combined with reduced intestinal absorption, leading to hypomagnesemia in up to 60 percent of heavy drinkers.
digoxin + licorice
Glycyrrhizin in licorice inhibits 11-beta-hydroxysteroid dehydrogenase type 2, mimicking aldosterone excess and causing sodium retention and potassium wasting. The resulting hypokalemia sensitizes the myocardium to digoxin and can trigger toxicity (arrhythmias, heart block) even at therapeutic serum digoxin levels.