arb
5 interactions related to arb
losartan + potassium
Losartan blocks the angiotensin II receptor, lowering aldosterone and reducing the amount of potassium the kidneys excrete. Adding concentrated potassium supplements or potassium-based salt substitutes can push serum potassium toward the hyperkalemic range, which carries cardiac arrhythmia risk in people with kidney impairment, diabetes, or heart failure. Routine monotherapy raises measured potassium only modestly in people with healthy kidneys, but the safety margin narrows once supplements or other potassium-raising drugs are added.
losartan + licorice
Glycyrrhizin in licorice mimics aldosterone, causing the kidneys to retain sodium and water while losing potassium. This pseudoaldosteronism raises blood pressure and works against losartan's antihypertensive effect, and the potassium loss can cause weakness and dangerous heart-rhythm problems.
losartan + hawthorn
Hawthorn modestly lowers blood pressure through vasodilation and endothelial effects. Taken with losartan, an angiotensin II receptor blocker, the two can add up and occasionally cause dizziness or lightheadedness, mainly in people who already run low or who take more than one blood pressure medication.
valsartan + spirulina
Spirulina has a modest blood-pressure-lowering effect in clinical trials and contributes a small amount of potassium. Combined with valsartan, the theoretical concerns are slightly additive blood pressure lowering and a minor contribution to potassium load. At usual supplement amounts neither effect is large, and for people with normal kidney function the combination is generally tolerable.
valsartan + potassium
Valsartan is an angiotensin II receptor blocker that suppresses aldosterone, which slows the kidneys' excretion of potassium. The FDA-approved Diovan label warns that potassium supplements and potassium-containing salt substitutes may raise serum potassium to clinically significant levels, particularly in people with reduced kidney function, diabetes, or heart failure.