antidepressants
2 interactions related to antidepressants
cannabis + ssris
Cannabinoids inhibit liver enzymes (including CYP2C19) that clear several SSRIs such as sertraline, citalopram, and escitalopram, which can raise SSRI plasma levels. Cannabinoids also touch the serotonin system, and case reports describe serotonin syndrome precipitated by high-potency cannabis in patients on serotonergic regimens.
coffee + antidepressants
Some antidepressants slow how fast the body clears caffeine by inhibiting the liver enzyme CYP1A2 — fluvoxamine does this most strongly, while fluoxetine, sertraline, paroxetine, and duloxetine have milder effects. At the same time, caffeine independently worsens anxiety, insomnia, tremor, and a racing heart, the very symptoms antidepressants are often prescribed to relieve. With MAOIs, very high caffeine intake has been linked in case reports to blood pressure spikes.