antidepressants
2 interactions related to antidepressants
cannabis + ssris
Cannabis cannabinoids inhibit CYP2C19, CYP2C9, and CYP3A4, raising plasma levels of SSRIs such as sertraline, citalopram, and escitalopram. Cannabinoids also modulate serotonin signaling, and case reports describe serotonin syndrome precipitated by high-potency cannabis in patients on SSRIs.
cannabismarijuanassriserotonin syndromesertralinefluoxetinecitalopramantidepressantscyp2c19
coffee + antidepressants
Many antidepressants (especially fluvoxamine, fluoxetine, sertraline, duloxetine) inhibit CYP1A2 to varying degrees and slow caffeine clearance, while caffeine itself can worsen the anxiety, insomnia, tremor, and tachycardia that antidepressants are often prescribed to treat. MAOIs add a risk of caffeine-induced hypertensive episodes.
coffeeantidepressantsssrisnrimaoicyp1a2caffeineanxiety