antiarrhythmic

amiodarone + grapefruit

Grapefruit juice inhibits intestinal CYP3A4, raising oral amiodarone AUC by approximately 50% and peak levels by 84% while abolishing production of its active metabolite N-desethylamiodarone. The FDA-approved Pacerone label explicitly states grapefruit juice should not be consumed during oral amiodarone treatment.