antacid
4 interactions related to antacid
atenolol + calcium
Calcium salts taken together with atenolol form a complex in the gut that cuts atenolol's peak plasma level by roughly 51% and total exposure (AUC) by 32%, blunting its blood-pressure and heart-rate effects 12 hours later. The effect was first quantified in a 1981 pharmacokinetic study and is the main reason high-dose calcium and atenolol should be separated in time.
ketoconazole + calcium
Calcium carbonate antacids raise gastric pH above the threshold that ketoconazole needs to dissolve, reducing oral ketoconazole absorption and lowering antifungal blood concentrations.
levofloxacin + calcium
Calcium chelates levofloxacin in the gastrointestinal tract, reducing peak serum concentrations by 20 to 30 percent. While the area under the curve is less affected than with older fluoroquinolones, the drop in peak concentration can matter for organisms with MICs close to the breakpoint.
doxycycline + magnesium
Magnesium ions chelate doxycycline in the gastrointestinal tract, forming an insoluble complex that markedly reduces antibiotic absorption. Magnesium-containing antacids and supplements can lower doxycycline bioavailability by up to 90 percent.