amiodarone
2 interactions related to amiodarone
amiodarone + grapefruit
Grapefruit juice inhibits intestinal CYP3A4, raising oral amiodarone AUC by approximately 50% and peak levels by 84% while abolishing production of its active metabolite N-desethylamiodarone. The FDA-approved Pacerone label explicitly states grapefruit juice should not be consumed during oral amiodarone treatment.
amiodaronegrapefruitcyp3a4antiarrhythmicqt prolongationatrial fibrillationdrug-food interactionfda label warning
methimazole + iodine
Methimazole blocks new thyroid hormone synthesis but does not prevent the gland from using iodide already inside it. Adding a large iodine load (kelp, iodine drops, iodine-containing contrast, amiodarone) can fuel hormone production, blunt methimazole's effect, and in some cases precipitate worsening hyperthyroidism or thyroid storm.
methimazoleiodinehyperthyroidismgraves diseasekelpcontrastamiodaronethyroid storm