amiodarone
2 interactions related to amiodarone
amiodarone + grapefruit
Grapefruit and grapefruit juice inhibit intestinal CYP3A4, the enzyme that metabolizes oral amiodarone. This raises amiodarone blood levels and largely shuts down production of its active metabolite, N-desethylamiodarone. The FDA-approved Pacerone label explicitly states grapefruit juice should not be consumed during oral amiodarone treatment.
amiodaronegrapefruitcyp3a4antiarrhythmicqt prolongationatrial fibrillationdrug-food interactionfda label warning
methimazole + iodine
Methimazole blocks new thyroid hormone synthesis but does not prevent the gland from using iodide already inside it. Adding a large iodine load (kelp, iodine drops, iodine-containing contrast, amiodarone) can fuel hormone production, blunt methimazole's effect, and in some people worsen hyperthyroidism or, rarely, precipitate thyroid storm.
methimazoleiodinehyperthyroidismgraves diseasekelpcontrastamiodaronethyroid storm