aldactone
2 interactions related to aldactone
spironolactone + potassium
Spironolactone makes your body hold on to potassium instead of flushing it out. Adding a potassium supplement, salt substitute, or potassium-loaded diet on top of that can push blood potassium to a dangerous level.
spironolactonepotassiumhyperkalemiaaldactonepotassium-sparing diureticheart failurecontraindicationmineralocorticoid
spironolactone + licorice
Glycyrrhizin in licorice is converted to glycyrrhetinic acid, which inhibits the kidney enzyme 11-beta-hydroxysteroid dehydrogenase type 2. This lets cortisol stimulate the mineralocorticoid receptor - the same receptor spironolactone is designed to block. The two pull in opposite directions: licorice tends to raise blood pressure and lower potassium, while spironolactone lowers blood pressure and raises potassium, so the herb can partially blunt the drug's intended effect.
spironolactonelicoriceglycyrrhizinpseudoaldosteronismaldactoneherb-drug interactionhypertensionmineralocorticoid