alcohol
40 interactions related to alcohol
alcohol + red yeast rice
Red yeast rice contains monacolin K, chemically the same as a statin, which carries a small, uncommon risk of liver injury. Alcohol is also hard on the liver, so combining the two — especially heavy or regular drinking — can add to the strain on the same organ.
alcohol + lithium
Lithium has a narrow therapeutic window and is cleared almost entirely by the kidneys. Alcohol promotes urination and dehydration, which can reduce renal lithium clearance and push serum lithium levels higher — toward the toxic range (tremor, confusion, unsteadiness, vomiting). Alcohol also independently destabilizes mood in bipolar disorder, and its early intoxication signs can mask the early warning signs of lithium toxicity.
alcohol + warfarin
Alcohol affects warfarin in two opposing directions: acute heavy drinking slows the liver's metabolism of warfarin, which can raise INR and bleeding risk, while sustained heavy drinking induces those same enzymes and can lower INR, increasing clot risk. Alcohol also impairs platelets and can damage the liver where clotting factors are made, and intoxication raises fall risk, all of which compound the bleeding hazard.
alcohol + kava
Kava and alcohol both depress the central nervous system, producing additive sedation and impaired coordination. More importantly, both are hepatotoxic: kava is a well-documented cause of severe and occasionally fatal liver injury, and alcohol adds a second liver stressor.
alcohol + glipizide
Alcohol can potentiate the glucose-lowering effect of glipizide and, rarely, provoke a disulfiram-like flushing reaction; the main risk is prolonged hypoglycemia.
metronidazole + alcohol
Metronidazole is traditionally said to cause a disulfiram-like reaction with alcohol — flushing, nausea, and headache. Controlled human studies have not reproduced a true disulfiram reaction, so the effect appears real but uncommon and usually mild. Most product labels still advise avoiding alcohol during treatment and for a short period afterward as a precaution.
alcohol + zolpidem
Zolpidem (Ambien) and alcohol both increase activity at the GABA-A receptor, producing additive sedation, impaired psychomotor performance, and an elevated risk of complex sleep behaviors, falls, and — at higher levels of intoxication — respiratory depression. The combination is an additive pharmacodynamic effect; the FDA interaction study found no change in zolpidem blood levels from alcohol.
alcohol + venlafaxine
Venlafaxine (Effexor) is an SNRI antidepressant, and alcohol is a central nervous system depressant. The FDA-approved label advises avoiding alcohol because the combination can add to drowsiness and dizziness and can worsen the mood or anxiety disorder being treated. The concern is about additive sedation, blood pressure, and undermined treatment rather than a dramatic pharmacokinetic clash, which is why it is rated moderate.
alcohol + duloxetine
Duloxetine (Cymbalta) can occasionally cause liver injury, and its FDA label advises against prescribing it to people with substantial or chronic alcohol use or existing liver disease, because both substances stress the liver. Documented cases have generally been reversible after stopping the drug, with no clear pattern of alcohol-linked liver failure in the published case series.
alcohol + amitriptyline
Amitriptyline is a sedating tricyclic antidepressant with strong antihistaminic and anticholinergic effects. Combining it with alcohol — also a central nervous system depressant — produces additive drowsiness, impaired coordination and reaction time, and a greater risk of falls and accidents. The FDA label warns explicitly that amitriptyline may enhance the response to alcohol.
alcohol + alprazolam
Alcohol and alprazolam (Xanax) both depress the central nervous system by enhancing GABA-A receptor activity. Taken together they produce additive — and sometimes synergistic — sedation, slowed breathing, and impaired coordination, which substantially raises the risk of overdose and death even when neither is taken in a large amount.
alcohol + diazepam
Diazepam (Valium) and alcohol are both central nervous system depressants that act on the GABA-A receptor, producing additive and sometimes greater-than-additive sedation with a real risk of dangerously slowed breathing, loss of consciousness, and death. Diazepam and its active breakdown products linger in the body for days, so the dangerous window extends well beyond a single dose.
alcohol + pregabalin
Pregabalin and alcohol are both central nervous system depressants. Taken together their sedative effects add up, increasing drowsiness, dizziness, and impaired coordination, and at the serious end can cause life-threatening respiratory depression — a risk highlighted by FDA and MHRA safety warnings.
alcohol + trazodone
Trazodone and alcohol both depress the central nervous system, producing additive sedation, dizziness, orthostatic hypotension, and impaired coordination. The FDA label states trazodone may enhance the response to alcohol, and combining the two raises the risk of falls and accidents. Rarely, trazodone is associated with QT prolongation, orthostatic syncope, and priapism.
alcohol + tramadol
Tramadol combined with alcohol produces additive central nervous system and respiratory depression, and the combination lowers the seizure threshold, increasing the risk of convulsions, serotonin-related reactions, and life-threatening overdose. Tramadol's serotonergic and noradrenergic activity makes this pairing more hazardous than alcohol with a typical opioid.
alcohol + naproxen
Naproxen is a long-acting NSAID that weakens the stomach's protective lining and blunts platelet function. Adding alcohol stacks several forms of damage on top of each other, and naproxen's long action keeps that interaction window open well beyond the last dose.
alcohol + codeine
Codeine and alcohol are both central nervous system depressants. Taken together they add up, slowing breathing and deepening sedation, with the risk of dangerous or fatal respiratory depression. The danger is amplified for people who convert codeine to morphine unusually fast (CYP2D6 ultra-rapid metabolizers), who can experience strong opioid effects from ordinary doses.
alcohol + mirtazapine
Mirtazapine and alcohol both depress the central nervous system, producing additive sedation, drowsiness, and impaired coordination and judgment. Mirtazapine's strong H1-antihistamine activity makes the sedative interaction with alcohol particularly pronounced, and the FDA label specifically advises avoiding alcohol during treatment.
alcohol + hydrocodone
Hydrocodone and alcohol are both central nervous system depressants. Taken together they cause additive depression of the brainstem breathing centers, which can lead to profound sedation, dangerously slowed or stopped breathing, coma, and death even at otherwise-tolerated opioid doses. Some extended-release hydrocodone formulations can also "dose dump" when combined with alcohol, releasing the dose prematurely. Hydrocodone-acetaminophen products add a separate alcohol-related liver-injury risk.
alcohol + propranolol
Alcohol and propranolol can produce additive drops in blood pressure with dizziness, lightheadedness, and fainting through combined vasodilation and a blunted heart-rate response. Propranolol can also mask the racing-heart and shakiness warning signs of low blood sugar, and alcohol can raise propranolol levels in the body.
alcohol + statins
Statins and alcohol are both processed by the liver, and heavy or chronic combined use can add to the strain on liver cells, modestly raising the risk of liver enzyme elevation and, less commonly, muscle problems. In people with established alcohol-related liver disease, statin levels in the blood can run higher than normal. For most people who drink lightly to moderately, a statin is still safe with routine monitoring.
alcohol + hydrochlorothiazide
Hydrochlorothiazide and alcohol both lower blood pressure and increase fluid loss, so taking them together can cause additive dizziness, lightheadedness on standing, and fainting. Both can also worsen loss of potassium and magnesium. The interaction is usually manageable at light drinking levels but becomes more significant in older adults, in hot weather, and during illness.
alcohol + folate
Chronic alcohol use causes folate deficiency through several mechanisms: it inhibits the reduced folate carrier in the intestine (blocking absorption), reduces the liver's uptake and storage of folate, and increases urinary folate loss. Folate depletion in turn accelerates alcohol-induced liver injury and disrupts one-carbon metabolism and DNA methylation.
alcohol + digoxin
There is no major direct chemical clash between alcohol and digoxin, but alcohol works indirectly to make digoxin less safe. Alcohol can trigger irregular heart rhythms (so-called holiday heart) and, along with diuretics, deplete potassium and magnesium. Because digoxin has a narrow safety margin, those electrolyte shifts make the heart more sensitive to it and raise the risk of digoxin toxicity. Heavy drinking can also worsen the heart failure digoxin is meant to treat.
alcohol + zinc
Chronic alcohol use lowers the body's zinc through reduced intake, impaired intestinal absorption, increased urinary loss, and altered zinc transporters (notably ZIP14). The relationship is bidirectional: zinc deficiency in turn worsens alcohol-related liver injury by weakening the intestinal barrier, allowing more bacterial endotoxin to leak into the portal blood, and reducing the liver's antioxidant defenses.
thc + alcohol
Drinking alcohol alongside cannabis raises the peak blood level of THC and its active metabolite from the same amount of cannabis, and the two substances produce additive impairment of coordination, judgment, and reaction time. The combination is one of the most frequently detected in drivers involved in fatal crashes.
alcohol + valerian
Valerian and alcohol both act on the GABA-A receptor system and are central nervous system depressants. Combining them carries a recognized possibility of additive sedation — more drowsiness, slower reactions, and impaired coordination than either alone. Most of this rests on shared mechanism and expert caution rather than large human outcome trials, but the practical concern is real: impaired driving and falls, particularly in older adults.
alcohol + celecoxib
Combining alcohol with celecoxib increases the risk of gastrointestinal irritation, ulcers, and bleeding, and adds stress to the liver and kidneys. Celecoxib's COX-2 selectivity makes it gentler on the stomach than older NSAIDs, but the FDA label still names alcohol as a factor that raises GI-bleeding risk.
alcohol + sertraline
Sertraline (Zoloft) and alcohol both act on the central nervous system. Controlled studies in healthy volunteers did not show sertraline worsening alcohol's effects on thinking or coordination, but the FDA label still advises against drinking on sertraline because alcohol can deepen depression and anxiety, worsen drowsiness and sleep, and blunt the medication's benefit in people being treated for a mood disorder.
alcohol + aspirin
Aspirin and alcohol both damage the gastric lining and impair clotting; used together they raise the risk of upper gastrointestinal bleeding, with risk rising as alcohol intake and aspirin use increase.
alcohol + fluoxetine
Fluoxetine (Prozac) is an SSRI antidepressant, and alcohol is a central nervous system depressant. The FDA-approved Prozac label states that alcohol use is not recommended while taking fluoxetine. Fluoxetine and its active metabolite norfluoxetine also have unusually long half-lives, so the drug stays in your system for weeks once you reach steady state — there is no simple "timing window" that avoids the interaction. Notably, a controlled human study found that alcohol did not measurably increase fluoxetine's psychomotor impairment, so the combined sedative effect is more modest than once assumed; the precaution remains sensible but is not an emergency.
alcohol + gabapentin
Gabapentin and alcohol are both central nervous system depressants. Combining them increases drowsiness, dizziness, impaired coordination, and the risk of serious, potentially life-threatening respiratory depression, especially in older adults and people with lung disease, sleep apnea, kidney impairment, or who take opioids or other sedatives.
alcohol + thiamine
Alcohol depletes thiamine (vitamin B1) at multiple levels — reducing its absorption from the gut, impairing the liver's ability to convert it to its active form, and increasing how much is lost in urine. In heavy drinkers this can lead to Wernicke encephalopathy, a neurologic emergency, which if untreated may progress to Korsakoff syndrome, a chronic and often irreversible memory disorder.
alcohol + nac
N-acetylcysteine (NAC) is a precursor to glutathione, the antioxidant the liver uses to neutralize acetaldehyde, the toxic intermediate of alcohol metabolism. The mechanism is plausible and animal studies show reduced alcohol-induced oxidative stress, but human trials are mixed-to-negative: the best controlled studies found no meaningful effect on hangover symptoms or oxidative markers. NAC does not protect against the cumulative harms of drinking.
alcohol + magnesium
Alcohol acts as an acute magnesium diuretic, increasing urinary magnesium excretion within hours of intake. Regular and heavy drinking can deplete body magnesium stores through renal wasting combined with reduced intestinal absorption and poor diet, and low magnesium is common in chronic alcohol-use disorder.
alcohol + vitamin a
Alcohol depletes the liver's vitamin A by inducing cytochrome P450 enzymes (notably CYP2E1) that break retinol down into toxic byproducts. Adding high-dose vitamin A or beta-carotene supplements on top of regular drinking can worsen liver injury rather than correct the deficiency, so repletion in drinkers is not as simple as taking a pill.
alcohol + ibuprofen
Alcohol and ibuprofen each irritate the stomach lining and impair platelet function, and combining them raises the risk of gastrointestinal bleeding and ulcers. Both also stress the kidneys — ibuprofen reduces renal blood flow while alcohol drives dehydration — which can add up to acute kidney injury, especially in older adults or people with existing kidney problems.
alcohol + nitroglycerin
Both nitroglycerin and alcohol widen blood vessels, so taking them together can lower blood pressure more than either does alone. This additive drop can cause dizziness, fainting, or worsened chest pain, and it is most pronounced with fast-acting sublingual tablets or spray. The combination has been recognized since an early case report in the New England Journal of Medicine in 1965.
alcohol + insulin
Alcohol suppresses the liver's production of new glucose (gluconeogenesis), removing a key safety net against low blood sugar, while insulin lowers glucose directly. Combined, they can cause severe, prolonged, and delayed hypoglycemia, especially when drinking on an empty stomach or in the evening.
alcohol + oxycodone
Alcohol and oxycodone are both central nervous system depressants. Taken together they add up, slowing breathing and deepening sedation to a degree that can be life-threatening even when each amount would be tolerated alone. The FDA carries its strongest (boxed) warning on this combination, and national mortality data show alcohol is involved in a meaningful share of opioid overdose deaths.