1 interaction related to addiction medicine
Methadone is partially metabolized by CYP3A4 (and CYP2B6). Grapefruit juice inhibits intestinal CYP3A4 and can raise methadone plasma concentrations, with case reports of opioid toxicity after sustained grapefruit juice intake. Higher methadone levels also increase the risk of QT prolongation and torsades de pointes.