ace inhibitor
11 interactions related to ace inhibitor
lisinopril + potassium
Lisinopril blocks the renin-angiotensin-aldosterone system, reducing aldosterone secretion and impairing the kidneys' ability to excrete potassium. Adding potassium supplements on top of this can push serum potassium into dangerous territory, especially in older adults or those with reduced kidney function.
lisinopril + salt substitutes
Potassium-based salt substitutes (potassium chloride replacing sodium chloride) can deliver hundreds of milligrams of potassium per teaspoon. Combined with lisinopril's impairment of renal potassium excretion, this combination has caused multiple documented cases of life-threatening hyperkalemia, including cardiac arrest.
lisinopril + licorice
Glycyrrhizin in licorice mimics aldosterone, causing the kidneys to retain sodium and water and excrete potassium. This raises blood pressure and directly opposes lisinopril's antihypertensive effect, while also driving hypokalemia that can complicate other cardiovascular risks.
radish + ace inhibitors
Radish contains moderate amounts of dietary nitrate and potassium. Nitrate becomes nitric oxide and modestly relaxes blood vessels, while potassium adds to the elevated potassium levels that ACE inhibitors already cause. In normal food portions the effect is small, but very large or supplement-level intake can matter.
lithium + ace inhibitors
ACE inhibitors reduce glomerular filtration rate and decrease sodium delivery to the distal nephron, which lowers renal lithium clearance and can raise serum lithium by approximately 36 percent. Toxicity may emerge with delayed onset 3 to 5 weeks after starting the ACE inhibitor, particularly in older adults and those with reduced renal function.
oranges + ace inhibitors
Oranges and orange juice are high in potassium (about 240 mg per medium orange, 450-500 mg per cup of juice), and ACE inhibitors reduce aldosterone and renal potassium excretion. Heavy consumption of oranges or orange juice with ACE inhibitors can raise serum potassium, with greater risk in patients with reduced kidney function.
potatoes + ace inhibitors
Potatoes are very high in potassium (a medium baked potato with skin contains about 900 mg), and ACE inhibitors reduce aldosterone-mediated potassium excretion. Regular large servings of potatoes combined with ACE inhibitors can raise serum potassium, particularly in patients with chronic kidney disease, heart failure, or diabetes.
celery juice + blood pressure medications
Celery contains phthalides (including 3-n-butylphthalide), nitrate, and other constituents that relax vascular smooth muscle and have demonstrated blood pressure lowering effects in animal and small human studies. Large daily celery juice intake can add to the effect of antihypertensive drugs, including ACE inhibitors, calcium channel blockers, and diuretics.
salt substitute + lisinopril
Salt substitutes are typically potassium chloride and can deliver hundreds of milligrams of potassium per small serving. Lisinopril and other ACE inhibitors reduce aldosterone and decrease potassium excretion. Combining them can cause clinically significant hyperkalemia, particularly with chronic kidney disease, diabetes, or other potassium-raising drugs.
bananas + lisinopril
Lisinopril is an ACE inhibitor that reduces aldosterone and increases serum potassium. Combined with high dietary potassium from bananas and other potassium-rich foods, this can cause hyperkalemia, particularly in patients with reduced kidney function or those also taking potassium-sparing diuretics.
avocado + ace inhibitors
Avocados are a high-potassium food (about 487 mg per half avocado), and ACE inhibitors reduce aldosterone-driven potassium excretion. Frequent large servings of avocado combined with ACE inhibitors can contribute to hyperkalemia, especially in patients with kidney impairment or other potassium-raising medications.