ace inhibitor
10 interactions related to ace inhibitor
lisinopril + potassium
Lisinopril blocks the renin-angiotensin-aldosterone system, lowering aldosterone and reducing the kidneys' ability to excrete potassium. Adding a potassium supplement or potassium-based salt substitute on top can push blood potassium into a dangerous range (hyperkalemia), especially in older adults or people with reduced kidney function.
lisinopril + salt substitutes
Most popular salt substitutes replace sodium chloride with potassium chloride, delivering a meaningful potassium load with every shake. Lisinopril, an ACE inhibitor, reduces the kidney's ability to excrete potassium. Used together, this combination has caused documented cases of life-threatening hyperkalemia, including emergencies requiring dialysis.
lisinopril + licorice
Glycyrrhizin in licorice mimics aldosterone, causing the kidneys to retain sodium and water and excrete potassium. This raises blood pressure and works against lisinopril's antihypertensive effect, while also lowering potassium, which can complicate cardiovascular risk.
lithium + ace inhibitors
ACE inhibitors lower the rate at which the kidneys clear lithium, so adding one to lithium therapy tends to raise serum lithium levels. Because lithium has a narrow safety margin, this can push levels toward the toxic range. A distinctive feature is delayed onset: toxicity may not appear for several weeks after the ACE inhibitor is started, especially in older adults and those with reduced kidney function.
oranges + ace inhibitors
Oranges and orange juice are rich in potassium, and ACE inhibitors reduce the kidneys' excretion of potassium by suppressing aldosterone. Drinking large daily volumes of orange juice while taking an ACE inhibitor can nudge serum potassium upward. The risk is real but modest for most people; it matters most in those with reduced kidney function, diabetes, or heart failure, or those also taking other potassium-raising medicines or supplements.
potatoes + ace inhibitors
Potatoes are one of the most concentrated dietary sources of potassium, and ACE inhibitors reduce how much potassium the kidneys excrete by lowering aldosterone. Regularly eating large servings of potatoes while taking an ACE inhibitor can nudge serum potassium upward, especially in people with chronic kidney disease, heart failure, or diabetes, or those taking other potassium-raising medicines.
celery juice + blood pressure medications
Celery contains phthalides (including 3-n-butylphthalide), nitrate, and potassium that relax blood vessels and have a mild blood-pressure-lowering effect demonstrated in a human trial of celery seed extract. Drinking celery juice regularly can add to the effect of antihypertensive drugs such as ACE inhibitors, ARBs, calcium channel blockers, and diuretics, potentially pushing blood pressure lower than intended.
salt substitute + lisinopril
Most salt substitutes replace sodium chloride with potassium chloride, making them a concentrated source of potassium. Lisinopril and other ACE inhibitors lower aldosterone and reduce the kidneys' ability to clear potassium. Used together, they can raise blood potassium to dangerous levels (hyperkalemia), especially in people with reduced kidney function, diabetes, older age, or who take other potassium-raising medicines.
bananas + lisinopril
Lisinopril is an ACE inhibitor that reduces aldosterone, so the kidneys hold onto more potassium and serum potassium tends to rise. A diet heavy in high-potassium foods like bananas can add to that load. For most people with normal kidneys this is a small, manageable effect; the risk of clinically meaningful hyperkalemia is greater in those with reduced kidney function, diabetes, heart failure, or who also take potassium-sparing diuretics, potassium supplements, or potassium-based salt substitutes.
avocado + ace inhibitors
Avocado is high in potassium, and ACE inhibitors reduce the kidneys' excretion of potassium by lowering aldosterone. Heavy, regular avocado intake combined with an ACE inhibitor — especially alongside other potassium sources or in people with reduced kidney function — can raise serum potassium toward hyperkalemia.