absorption interaction
11 interactions related to absorption interaction
levothyroxine + magnesium
Taking magnesium too close to levothyroxine can modestly reduce how much of the thyroid medicine is absorbed, because magnesium can bind levothyroxine in the gut.
antibiotics + calcium
Calcium can bind to certain antibiotics (tetracyclines and fluoroquinolones) in the gut and reduce how much of the drug is absorbed.
levothyroxine + iron
When taken at the same time, iron can reduce how much levothyroxine your body absorbs by forming a poorly soluble complex in the gut, which can blunt the effect of your thyroid medication and raise TSH.
omega-3 + vitamin d
Fat from omega-3 supports absorption of the fat-soluble vitamin D
curcumin + piperine
Piperine (black pepper extract) substantially increases how much curcumin your body absorbs.
levothyroxine + calcium
Calcium can reduce levothyroxine absorption when the two are taken close together
metformin + vitamin b12
Long-term metformin use can reduce vitamin B12 absorption, sometimes enough to cause deficiency.
vitamin c + iron
Vitamin c enhances absorption of non-heme iron from supplements and plant foods, a beneficial nutrient synergy, though the real-world benefit across a full diet is usually modest.
calcium + iron
Calcium can reduce the absorption of iron when the two are taken together, with the effect most pronounced for non-heme iron from supplements and plant foods.
iron + zinc
High-dose iron and zinc supplements can compete for absorption in the small intestine when taken together, especially in solution on an empty stomach, potentially reducing the effectiveness of one or both minerals. The competition is minimal when the minerals are taken with food or hours apart, or at ordinary dietary amounts.
magnesium + zinc
At high supplemental doses, zinc and magnesium can each modestly reduce the other's absorption in the gut — and the better-documented direction is zinc lowering magnesium absorption, not the reverse. The effect is minor and dose-dependent; ordinary multivitamin amounts rarely matter.