absorption

14 interactions related to absorption

levothyroxine + calcium

Calcium significantly reduces levothyroxine absorption

high
levothyroxinecalciumabsorptionabsorption interactionsupplement timingthyroid medicationhypothyroidismTSHantacidscalcium supplements

levothyroxine + iron

Iron reduces levothyroxine absorption by up to 65%

high
levothyroxineironabsorptionabsorption interactionsupplement timingmedication timingthyroid medicationhypothyroidismTSHferrous sulfate

levothyroxine + magnesium

Magnesium can reduce levothyroxine absorption

high
levothyroxinemagnesiumabsorptionabsorption interactiondrug supplement interactionsupplement timingmedication timingTSHthyroid medicationantacids

curcumin + piperine

Piperine (black pepper extract) increases curcumin bioavailability by up to 2000%

low
curcuminpiperineabsorptionabsorption interactionnutrient synergysupplement interactionsupplement timingdrug supplement interaction

vitamin c + iron

Vitamin C significantly enhances non-heme iron absorption (up to 6x)

low
vitamin cironabsorptionabsorption interactioniron absorptioniron deficiencyiron deficiency anemiaferrous sulfatesupplement timing

omega-3 + vitamin d

Fat from omega-3 improves fat-soluble vitamin D absorption

low
omega-3vitamin dabsorptionabsorption interactionfat-soluble vitaminsfish oilsupplement timingbone healthnutrient synergy

magnesium + zinc

High-dose magnesium (>142mg) can interfere with zinc absorption

moderate
magnesiumzincabsorptionabsorption interactionsupplement timingmineral absorptionzinc absorptionzinc supplementZMA supplements

calcium + iron

Calcium inhibits iron absorption by up to 60%

moderate
calciumironabsorptionabsorption interactioniron absorptionsupplement timingcalcium supplementferrous sulfateprenatal vitamins

antibiotics + calcium

Calcium can bind to certain antibiotics and reduce their absorption

moderate
antibioticscalciumabsorptionabsorption interactiondrug nutrient interactiondrug supplement interactionsupplement timingciprofloxacindoxycycline

St. John's Wort + SSRI

St. John's Wort induces cytochrome P450 enzymes and P-glycoprotein, reducing plasma concentrations of SSRIs and increasing the risk of serotonin syndrome when combined due to additive serotonergic effects.

high
st. john's wortssridrug interactiondrug supplement interactionsupplement interactionsupplement interactionsmedication timingabsorption

metformin + vitamin b12

Long-term metformin use depletes vitamin B12 levels

high
metforminvitamin b12absorptionabsorption interactiondrug nutrient interactiondrug supplement interactionsupplement interactionsupplement timingantacids

vitamin d + magnesium

Magnesium is needed to convert vitamin D into its active form

low
vitamin dmagnesiumnutrient synergyabsorptionbone healthcalcium metabolismsupplement timingvitamin d absorptionZMA supplements

antibiotics + probiotics

Antibiotics kill probiotic bacteria, reducing their effectiveness

moderate
antibioticsprobioticssupplement timingdrug supplement interactionabsorptionmedication timingciprofloxacindoxycycline

iron + zinc

Iron and zinc compete for absorption when taken together in high doses

moderate
ironzincabsorptionabsorption interactioniron absorptionzinc absorptionsupplement timingferrous sulfateprenatal vitaminsZMA supplements
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