5-hydroxytryptophan
2 interactions related to 5-hydroxytryptophan
sertraline + 5-htp
Sertraline blocks serotonin reuptake and 5-HTP (5-hydroxytryptophan) is the immediate precursor of serotonin, so it directly increases serotonin synthesis. Combining the two stacks production and reuptake blockade, which can precipitate serotonin syndrome.
sertraline5-htp5-hydroxytryptophanssriserotonin syndrometryptophansupplementantidepressantwarning
fluoxetine + 5-htp
Fluoxetine is an SSRI that blocks serotonin reuptake, and 5-HTP is a direct precursor the body converts into serotonin. Combining them can push serotonin to levels associated with serotonin syndrome, and fluoxetine's long-lived active metabolite norfluoxetine extends this risk for weeks after the last dose.
fluoxetineprozac5-htp5-hydroxytryptophanssriserotonin syndrometryptophansupplementwarning